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Acetaminophen (Tylenol®)

Acetaminophen (Tylenol®)

Alternate Test Name

Tylenol®

Epic Mnemonic
Sunquest Mnemonic

LAB43
ACEM

Category

Chemistry

Methodology

Homogenous Enzyme Immunoassay

Test Performance Schedule

Sunday - Saturday

Result Availability

Within 24 hours – STAT upon request

Specimen Required

Container

  Red top (serum), or Green to (lithium heparin) tube
Alt: EDTA, Red

Volume

Pref. Vol.: 1.0 mL
Min. Vol.: 0.5 mL

Collection Instructions

• Routine venipuncture

• Immediately after collection, gently invert tube 5-10 times

• Clot 30 minutes

• Promptly centrifuge 

• if no gel barrier is present immediately transfer serum or plasma to a plastic tube and refrigerate

• Properly centrifuged gel barrier tube does not require transfer of serum or plasma to separate tube

Transportation Instructions

Refrigerated

Stability

• Refrigerated: 5 days

Causes for Rejection

Icteric Specimens: Bilirubin interference may cause erroneous Acetaminophen results.

Hemolyzed Specimens: Hemolysis causes a significant interference with the acetaminophen assay.

CPT Codes

80143

Effective/Revised

03/20/2017

Clinical Significance

Acetaminophen is a common drug used in many formulations due to its analgesic and antipyretic properties. Chronic excessive use of acetaminophen can result in hepatotoxicity and nephrotoxicity. Overdosage can lead to severe hepatic damage and hepatic failure if untreated. Early diagnosis of acetaminophen induced hepatotoxicity is important since initiation of therapy within 16 hours of ingestion lessens the potential for hepatic injury and decreases the mortality rate. Therefore, a rapid and accurate determination of acetaminophen is needed.

 

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