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Activated Protein C Resistance

Activated Protein C Resistance
Epic Mnemonic Sunquest Mnemonic	LAB846 APCR
Category	Sendouts
Methodology	RVVT-based Assay (Clot-based)
Test Performance Schedule	Monday, Wednesday, Friday
Result Availability	3 – 5 days

Specimen Required

Container	Light blue top tube (3.2% buffered sodium citrate)
Volume	Pref. Vol.: 1.0 mL plasma
Collection Instructions	• Routine venipuncture • Immediately after collection, gently invert tube 5-10 times • Specimen must be processed within 1 hour of collection • Platelet-poor plasma: Centrifuge light-blue top for 15 minutes at approximately 1500 g within 1 hour of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer, and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (<10,000/mcL). • Separate plasma into plastic tube (1.0 mL minimum) • Freeze immediately
Transportation Instructions	Frozen
Stability	• Room temperature: 1 hour (whole blood state) • Refrigerated: Unacceptable • Frozen: 6 months
Causes for Rejection	• Citrate tube underfilled • Sample clotted or hemolyzed • Platelet-poor plasma not frozen within 1 hours of collection
Remarks	Platelet-poor plasma (PPP) samples obtained by double centrifugation are critical for accurate coagulation studies as platelet contamination may cause spurious results
CPT Codes	85307
Effective/Revised	8/15/2019

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