Apolipoprotein B, Serum

Apolipoprotein B, Serum

Alternate Test Name

Alternate Name

Epic Mnemonic
Sunquest Mnemonic

LAB3364
ALIPB

Category

Sendouts

Methodology

Automated Turbidimetric Immunoassay

Test Performance Schedule

Sunday - Saturday

Result Availability

2 – 3 days

Container

Gold to (SST) tube
Red top (serum) tube also acceptable

Volume

Pref. Vol.: 1.0 mL
Min. Vol.: 0.5 mL

Collection Instructions

• Routine venipuncture
• Immediately after collection, gently invert tube 5-10 times
• Clot 30 minutes
• Centrifuge within 2 hours of collection
• Refrigerate

Transportation Instructions

Refrigerated

Stability

• Room Temperature: :24 hours
• Refrigerated: 8 days
• Frozen: 6o days

Causes for Rejection

Gross hemolysis, gross icterus

CPT Codes

82172

Effective/Revised

12/14/2022

Apolipoprotein B (ApoB) is the primary protein component of low-density lipoprotein (LDL). The amount of cholesterol contained within LDL varies, but each LDL contains exactly one ApoB protein. Therefore, ApoB is a more reliable indicator of circulating LDL compared to LDL cholesterol (LDL-C). ApoB has been demonstrated to perform equally with LDL particles measured by nuclear magnetic resonance spectroscopy.(1)

ApoB is strongly associated with increased risk of developing cardiovascular disease (CVD) and often outperforms LDL-C at predicting risk of coronary heart disease.(2-4) Patients with acceptable non-high-density lipoprotein cholesterol (HDL-C) or LDL-C but elevated ApoB remain at higher risk of developing CVD; conversely, patients with acceptably low ApoB but moderate non-HDL-C or LDL-C elevations are at a reduced risk for CVD.(5,6)

Finally, in 7 different placebo-controlled randomized clinical trials, on-statin reduction of ApoB was more closely related to CVD risk reduction than non-HDL-C or LDL-C.(7)