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Hepatitis B Core Antibodies - IgG/IgM (Total Only)

Hepatitis B Core Antibodies, IgG/IgM (Total Only)

Epic Mnemonic
Sunquest Mnemonic

LAB1242
HBCT

Category

Chemistry

Methodology

Electrochemiluminescence immunoassay

Test Performance Schedule

Sunday - Saturday

Result Availability

Within 24 hours

Specimen Required

Container

Gold top (SST), Red top (serum), or Green top (lithium heparin) tube

Volume

Pref. Vol.: 1.0 mL serum or plasma
Min. Vol.: 0.5 mL serum or plasma

Collection Instructions

• Routine venipuncture

• Immediately after collection, gently invert tube 5-10 times

• Clot 30 minutes

• Promptly centrifuge 10 minutes

• If no gel barrier is present immediately transfer serum or plasma to a plastic tube and refrigerate

• Properly centrifuged gel barrier tube does not require transfer of serum or plasma to separate tube

Transportation Instructions

Refrigerated

Stability

Refrigerated: 5 days

Remarks

Medicare Medical Necessity Policy

Biotin, also referred to as Vitamin B7 or Vitamin H, can interfere with this test when taken in mega doses of 5mg (5000 mcg) or more. It is often promoted as a skin and hair beauty aid. Please ask your patients to refrain from taking Biotin or supplements containing Biotin for at least 24 hours before collecting specimens for lab testing.

https://biotinfacts.roche.com/

https://www.fda.gov/medicaldevices/safety/alertsandnotices/ucm586505.htm

CPT Codes

86704

Effective/Revised

7/31/2019

Clinical Significance

During an infection with the hepatitis B virus, antibodies to the hepatitis B core antigen (HBcAg) are generally formed, which often persist for life. Anti-HBc appears shortly after the onset of infection with hepatitis B virus and can usually be detected in serum soon after the appearance of HBsAg. Anti-HBc antibodies persist both in persons who have recovered from a hepatitis B infection and in those who develop HBsAg-carrier status. Accordingly, they are an indicator of existing or past hepatitis B infection.

 

In rare cases, an HBV infection can also run its course without the appearance of immunologically detectable anti-HBc (usually in immunosuppressed patients).

 

Due to the long persistence of anti-HBc following a hepatitis B viral infection, screening for HBV infection may be accompanied by testing for the presence of hepatitis B core antibodies as long as those who test positive are further tested for both HBsAg and anti-HBs to differentiate infection from immunity. In the absence of other hepatitis B markers (HBsAg-negative persons), anti-HBc may be the only indication of an existing hepatitis B viral infection.

 

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