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Paraneoplastic Autoantibody Evaluation, Serum

Paraneoplastic, Autoantibody Evaluation, Serum

Alternate Test Name

Neuronal Nuclear Antibodies (Hu & Ri)

Epic Mnemonic
Sunquest Mnemonic

LAB2007
ANNABB

Category

Sendouts

Methodology

Indirect Immunofluorescence Assay (IFA)
Enzyme-Linked Immunosorbent Assay (ELISA)
Radioimmunoassay (RIA)
Western Blot
Cell-Binding Assay (CBA)
Live Cell Assay (LCA)

Test Performance Schedule

Varies depending on testing performed

Result Availability

10 days (negative)

Specimen Required

Container

Gold top (SST) or Red top serum tube

Volume

Pref. Vol.: 4.0 mL
Min. Vol.: 2.0 mL

Collection Instructions

• Routine venipuncture
• Serum samples clot 30 minutes
• Promptly centrifuge 15 minutes
• Immediately transfer red top serum to a separate plastic tube
• Refrigerate

Transportation Instructions

Refrigerated

Stability

• Room Temperature: 72 hours
• Refrigerated (preferred): 28 days
• Frozen: 28 days

Causes for Rejection

Grossly hemolyzed, lipemic, or icteric specimens

Remarks

Patient Preparation:
• For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication
• This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, because of potential assay interference. The specific waiting period before specimen collection will depend on the isotope administered, the dose given, and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received in the laboratory will be held 1 week and assayed if sufficiently decayed, or canceled if radioactivity remains.
• Patient should have no general anesthetic or muscle-relaxant drugs in the previous 24 hours

Profile Information:
ANNA-2, S
ANNA-3, S
N-Type Calcium Channel Ab
P/Q-Type Calcium Channel Ab
CRMP-5-IgG, S
AChR Ganglionic Neuronal Ab, S
Interpretive Comments
PCA-2, S
PCA-1, S
PCA-Tr, S
Striational (Striated Muscle) Ab, S
Neuronal (V-G) K+ Channel Ab, S
AGNA-1, S
Amphyiphysin Ab, S
ANNA-1, S
Reflex testing per Algorithm

CPT Codes

83519 x 4
86255 x 9
83520
Additional CPT codes may apply based upon Reflex testing

Effective/Revised

11/19/2019

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