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Theophylline (Aminophylline)

Theophylline (Aminophylline®)

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LAB35
THEO

Category

Chemistry

Methodology

KIMS Assay

Test Performance Schedule

Sunday - Saturday

Result Availability

Within 24 hours – STAT upon request

Specimen Required

Container

Preferred: Gold top (SST), Red top (serum), or Green top (lithium heparin) tube
Alt: Lavender top (EDTA) tube

Volume

Pref. Vol.: 1.0 mL serum
Min. Vol.: 0.5 mL serum

Collection Instructions
  • Routine venipuncture
  • Immediately after collection, gently invert tube 5-10 times
  • Clot 30 minutes
  • Promptly centrifuge 10 minutes
  • If no gel barrier is present immediately transfer serum or plasma to a plastic tube and refrigerate
  • Properly centrifuged gel barrier tube does not require transfer of serum or plasma to separate tube

Transportation Instructions

Refrigerated

Stability

• Refrigerated: 5 days

CPT Codes

80198

Clinical Significance

Theophylline, a bronchodilator, is widely used to treat patients with asthma, apnea (temporary asphyxia), and other obstructive lung diseases.

 

Monitoring of theophylline concentrations in serum is essential, since individuals can vary in their rates of theophylline clearance and severe toxicity has been observed without prior occurrence of minor side effects. Moreover, several factors can alter theophylline elimination. Theophylline elimination is slowed in obese patients, patients with hepatic disease, and in those on a high carbohydrate, low protein diet. Premature infants have very low rates of theophylline elimination. Conversely, theophylline elimination is more rapid among cigarette smokers.

 

In combination with other clinical data, monitoring serum theophylline levels may provide the physician with useful information to aid in adjusting patient dosage to achieve optimal therapeutic effect while avoiding drug toxicity.

 

 

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