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Digoxin (Lanoxin®)

Digoxin (Lanoxin®)

Epic Mnemonic
Sunquest Mnemonic

LAB23
DIGO

Category

Chemistry

Methodology

KIMS assay

Test Performance Schedule

Sunday - Saturday

Result Availability

Within 24 hours – STAT upon request

Specimen Required

Container

Gold top (SST), Red top (serum), or Green top (lithium heparin) tube
Alt: EDTA - GREEN / RED

Volume

Pref. Vol.: 1.0 mL serum
Min. Vol.: 0.5 mL serum

Collection Instructions

• Routine venipuncture

• Immediately after collection, gently invert tube 5-10 times

• Clot 30 minutes

• Promptly centrifuge

• If no gel barrier is present immediately transfer serum or plasma to a plastic tube and refrigerate

• Properly centrifuged gel barrier tube does not require transfer of serum or plasma to separate tube

Transportation Instructions

Refrigerated

Stability

• Refrigerated: 24 hours

Causes for Rejection

Uzara and pentoxifylline were identified to cause falsely elevated digoxin values at concentrations of the recommended daily dose.

 

The manufacturer of Digoxin Immune Fab (Antibody fragment therapy) has stated that no immunoassay technique is suitable for quantitating digoxin in serum from patients undergoing this treatment.

 

Falsely elevated digoxin values might be obtained in patients undergoing digitoxin therapy.

Remarks

Medicare Medical Necessity Policy

CPT Codes

80162

Effective/Revised

03/23/2017

Clinical Significance

Digoxin is a digitalis glycoside that exerts a positive inotropic effect that subsequently increases the contractile response of the myocardial fibers in patients experiencing congestive heart failure. Cardiac glycosides also can produce several electrophysiologic effects that produce negative chronotropic effects on the human heart. These effects tend to slow down and regulate a rapid, irregular beat like that found in patients experiencing cardiac arrhythmias

 

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